Sonodynamic therapy reduces iron retention of hemorrhagic plaque
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چکیده
منابع مشابه
Recent advances of sonodynamic therapy in cancer treatment
Sonodynamic therapy (SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this ar...
متن کاملCurrent Status and Future Perspectives of Sonodynamic Therapy and Sonosensitiers.
The precaution and treatment for cancer become inevitable with the rising of morbidity and mortality. In this article, a promising new methodology for cancer treatment, sono-dynamic therapy (SDT) was introduced. In addition, we extensively reviewed the molec-ular mechanisms of SDT killing cancer and summarized the classification of sonosensi-tizers. At the same time, research progress of SDT in...
متن کاملEffects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages
BACKGROUND Inflammatory cells exhibit an elevated level of protoporphyrin IX (PpIX) after the administration of 5-aminolevulinic acid (ALA). Here, we investigate the sonodynamic effects of ALA-derived PpIX (ALA-PpIX) on macrophages, which are the pivotal inflammatory cells in atherosclerosis. METHODS AND RESULTS Cultured THP-1 macrophages were incubated with ALA. Fluorescence microscope and f...
متن کاملBerberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
Impaired autophagy in macrophages accompanies the progression of atherosclerosis and contributes to lipid loading in plaques and ineffective lipid degradation. Therefore, evoking autophagy and its associated cholesterol efflux may provide a therapeutic treatment for atherosclerosis. In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholester...
متن کاملMicrobubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy.
A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.
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ژورنال
عنوان ژورنال: Bioengineering & Translational Medicine
سال: 2020
ISSN: 2380-6761,2380-6761
DOI: 10.1002/btm2.10193